The purpose of this document is multifold. First, it is meant to guide clinical echocardiographers in the applications of strain with clear supporting evidence for its use. Second, updated clinical advice should encourage the hardware and software industries to develop improved algorithms. Third, it provides guidance to payers as to which applications of strain are most worthy of reimbursement. Finally, gaps in the technology and evidence base are identified in hopes of inspiring new developments and applications in the field. The clinical advice is based on expert opinion, as extensive randomized controlled trials using strain-based measures do not exist within this space. The document itself is organized into modules facilitating updates in specific advice as new evidence is published. The initial section covers technical developments since 2011 with emphasis on the EACVI-ASE Strain Standardization Task Force. The next section addresses the critical issue of establishing normal ranges in strain, particularly left ventricular global longitudinal strain (LVGLS). The bulk of the document discusses clinical applications for strain, including HF, cardio-oncology, ischemia, valvular heart disease, the right ventricle, the left atrium, exercise and dobutamine stress applications, and CHD.
Chairs
James D. Thomas, MD, FASE, FESC
Chair
Thor Edvardsen, MD, PhD, FESC
Co-Chair
Authors
Published Date
November 3, 2025
Source
JASE
Topic
- Guidelines
Language
- English
Technique
- 3D Echocardiography (3DE)
- Cardiac Resynchronization Therapy (CRT)
- Ejection Fraction (EF)
- Global Longitudinal Strain (GLS)
- Point of Care Ultrasound
- Right Ventricular Systolic Pressure (RVSP)
- Stoke Volume (SV)
- Strain
- Stress Echocardiography
- Tissue Doppler Imaging (TDI)
- Transcatheter Aortic Valve Implantation (TAVI)
- Transcatheter Aortic Valve Replacement (TAVR)
- Transthoracic Echo (TTE)
Disease
- Adult Congenital Heart Disease (ACHD)
- Amyloidosis
- Aortic Regurgitation (AR)
- Aortic Stenosis (AS)
- Atrial Septal Defect (ASD)
- COVID-19
- Cancer
- Cardio-Oncology
- Cardiomyopathy (CM)
- Cardiovascular Disease (CVD)
- Heart Failure (HF)
- Heart Failure with Preserved Ejection Fraction (HFpEF)
- Heart Failure with Reduced Ejection Fraction (HFrEF)
- Hypertrophic Cardiomyopathy (HCM)
- Hypertrophic Obstructive Cardiomyopathy (HOCM)
- Hypoplastic Left Heart Syndrome (HLHS)
- Left Ventricular Hypertrophy (LVH)
- Left Ventricular Outflow Tract ( LVOT)
- Mitral Regurgitation (MR)
- Mitral Stenosis (MS)
- Myocardial Infarction (MI)
- Non-Ischemic Heart Disease
- Nonvalvular Heart Disease
- Pulmonary Arterial Hypertension (PAH)
- Pulmonary Embolism (PE)
- Restrictive Cardiomyopathy (RCM)
- Structural Heart Disease (SHD)
- Tetralogy of Fallot (TOF)
- Transposition of the Great Arteries (TGA)
- Tricuspid Regurgitation (TR)
- Valvular Heart Disease (VHD)
- Ventricular Septal Defect (VSD)
Anatomy
- Left Atrial Appendage (LAA)
- Left Atrium (LA)
- Left Ventricle or Left Ventricular (LV)
- Left Ventricular Function (LVF)
- Mitral Valve (MV)
- Right Ventricle or Right Ventricular (RV)
- Tricuspid Valve (TV)
Audience
- Advanced Practice Practitioners
- Congenital
- Critical Care Physicians
- Fellows in Training
- Industry Partners
- Medical Students
- Nurse Practitioners
- Nurses
- Patients
- Pediatric
- Physician Assistants
- Physicians
- Sonographer Students
- Sonographers
- Veterinarians